Queensland is home to half the nation's fattest, laziest regions - and unless that changes, the state can expect a heart disease epidemic.

Forget beer - Queenslanders could soon be more famous for the four Xs on their clothing tags than their fresh pints.

That's according to the Heart Foundation, which has released new statistics about the nation's rising levels of inactivity and obesity.

The data, drawn from Australian Bureau of Statistics research, found the Sunshine State is home to five of the country's 10 laziest and fattest regions.

Leading the slow-moving pack is Darling Downs-Maranoa, with 75 per cent of the population not active enough to stay healthy.

About 44 per cent of people in this area are also obese.

Ipswich, Mackay, Fitzroy and Toowoomba are the other Queensland localities that make the top 10.

"We are largely a state of couch-dwellers," Heart Foundation Queensland Health Director Rachelle Foreman said.

"The truth is our waistlines are expanding while our physical activity is shrinking."

Physical inactivity coupled with poor eating habits was the perfect recipe for heart disease, she said.

Notably, the state's metropolitan areas fared a lot better in terms of fitness and obesity.

But more needs to be done to help whip the Queensland's heart disease danger zones in shape.

With this in mind, the Heart Foundation is calling for a Physical Activity Action Plan to be implemented by both federal and state governments.

"The decision to be active for at least thirty minutes a day and sit less is enough to reduce your heart disease risk," Ms Foreman said.