A prototype drug has provided protection for monkeys carrying the simian version of the AIDS virus, giving hope of a vaccine for HIV in humans.

Scientists say a new drug tested on monkeys has provided an astonishingly effective shield against an animal version of the AIDS virus, a major gain in the quest for an HIV vaccine.

Macaque monkeys given the drug were able to fend off high, repeated doses of the simian version of the human immunodeficiency virus (HIV), scientists reported on Wednesday in the journal Nature.

"We ... show a way to achieve long-lived, effective vaccine-like protection from HIV 1," the main group of viral strains in humans, said study leader Michael Farzan, a professor at the Scripps Research Institute in Florida.

The prototype drug, called eCD4-Ig, comprises two imitations of the receptors, or docking points, where HIV latches on to CD4 cells - the key defences of the immune cells.

The mimics latch on to the virus, tricking it into prematurely launching the docking procedure, which it can only execute once.

The scientists likened the effect to closing the door to an intruder and tossing away the key.

The drug provides "very, very strong protection", Farzan told AFP by email.

The paper reported on a 40-week experiment which showed that inoculated animals thrived even after being injected with four times the dose needed to infect macaques in a "control" group.

Further research, to be unveiled at a conference in Seattle next week, found that the treated macaques "continue to be protected from eight times and 16 times the infectious dose, more than a year after inoculation," Farzan said.

The search for a vaccine has been one of the most frustrating chapters of the AIDS saga.

Lab-dish tests have found that the drug also works on human HIV, which is very close to simian version of the virus.

"Of course, we still need to do further safety studies in both macaques and humans," before any trials can take place, Farzan stressed.

Since 1981, about 78 million people have been infected by the human immunodeficiency virus (HIV), which destroys immune cells and leaves the body exposed to tuberculosis, pneumonia and other opportunistic diseases.

Thirty-nine million have died, according to UN estimates.


Copyright AAP 2015